Hydrochloric Acid → N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride

HRID 743175노트

반응식

HRID 743175 반응식
[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:4]>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]([CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH3:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 15389029N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine

생성물 1

HCID 19423977N,N-Dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine hydrochloride수율 93%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

0.39 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 230 mg of N,N-dimethyl-2-[2-(4-phenylbutyl)phenoxy]ethylamine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was allowed to stand at room temperature. The crystals which precipitated were collected by filtration, washed with ethyl acetate and dried in vacuo, to give 241 mg (yield 93%) of the title compound as colorless crystals, melting at 170°-173° C.

후처리

  1. customto stand at room temperature
  2. customThe crystals which precipitated
  3. filtrationwere collected by filtration
  4. washwashed with ethyl acetate
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-2c61e95625014ed283fbc4d5ac7ac602
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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