Hydrochloric Acid → 1-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

HRID 743179노트

반응식

HRID 743179 반응식
[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 106907751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine

생성물 1

HCID 194239751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

0.2 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 130 mg of 1-methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was worked up in a similar manner to the procedure described in Example 1(c). The solvent was removed by distillation under reduced pressure, and the residue was dried in vacuo, to give 144 mg of the title compound as a colorless oil.

후처리

  1. customThe solvent was removed by distillation under reduced pressure
  2. customthe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-f466fb14676e4f0598b0488db598de97
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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