Hydrochloric Acid → 2-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochloride

HRID 743238노트

반응식

HRID 743238 반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH2:24][CH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[C:28]1([CH2:27][CH2:26][CH2:25][CH2:24][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][CH2:15][CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][NH:9]2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 108367361-t-Butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine

생성물 1

HCID 194239802-{2-[2-(4-Phenylbutyl)phenoxy]ethyl}piperidine hydrochloride수율 97%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

10 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 1.13 g of 1-t-butoxycarbonyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}piperidine [prepared as described in step (b) above] in 10 ml of dioxane, and the resulting mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was washed with hexane and dried in vacuo, to give 0.94 g (yield 97%) of the title compound as a colorless oil.

후처리

  1. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
  2. washThe resulting residue was washed with hexane
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-895a9fea50b34cfea0b7205a25fe6ae1
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

반응 노트

불러오는 중…