홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 2-(2-{2-[2-(4-Ethylphenyl)ethyl]phenoxy}ethyl)-1-methypiperidine hydrochloride

HRID 743310
노트
인쇄 미리보기

반응식

HRID 743310 반응식
[ClH:1].[CH2:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]2[CH:27]=[CH:26][CH:25]=[CH:24][C:13]=2[O:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][N:18]2[CH3:23])=[CH:6][CH:5]=1)[CH3:3].C(OCC)(=O)C>O1CCOCC1>[ClH:1].[CH2:2]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]2[CH:27]=[CH:26][CH:25]=[CH:24][C:13]=2[O:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][N:18]2[CH3:23])=[CH:8][CH:9]=1)[CH3:3]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 194238792-(2-{2-[2-(4-Ethylphenyl)ethyl]phenoxy}ethyl)-1-methylpiperidine

생성물 1

HCID 574976362-(2-{2-[2-(4-Ethylphenyl)ethyl]phenoxy}ethyl)-1-methypiperidine hydrochloride수율 82%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

0.6 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 0.650 g of 2-(2-{2-[2-(4-ethylphenyl)ethyl]phenoxy}ethyl)-1-methylpiperidine [prepared as described in step (a) above] in a suitable amount of ethyl acetate, and the resulting solution was concentrated by distillation under reduced pressure. The resulting oily residue was dissolved in ethyl acetate, and a small amount of diethyl ether was added to the solution, which was then allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.590 g (yield 82%) of the title compound as colorless crystals, melting at 101°-103° C.

후처리

  1. concentrationthe resulting solution was concentrated by distillation under reduced pressure
  2. dissolutionThe resulting oily residue was dissolved in ethyl acetate
  3. additiona small amount of diethyl ether was added to the solution, which
  4. customto stand at room temperature
  5. customThe crystals which precipitated
  6. filtrationwere collected by filtration
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-269cc9f8720e40b09e898e378749229a
출처 데이터셋
uspto-grants-1996_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05556864

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트