Hydrochloric Acid → HCID 10384875, 화합물

HRID 743365노트

반응식

HRID 743365 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1.[ClH:26]>O1CCOCC1>[ClH:26].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][C:11]2[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=2[O:13][CH2:14][CH2:15][C@@H:16]2[CH2:20][CH2:19][CH2:18][N:17]2[CH3:21])[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 10384876HCID 10384876, 화합물

생성물 1

HCID 10384875HCID 10384875, 화합물수율 81%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

0.829 g of (S)-2-(2-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine was dissolved in 10 ml of dioxane, and 1.83 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting oil was dissolved in 15 ml of ethyl acetate, and the solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.741 g (yield 81%) of the title compound as colorless crystals, melting at 133°-135° C.

후처리

  1. concentrationwas then concentrated by distillation under reduced pressure
  2. dissolutionThe resulting oil was dissolved in 15 ml of ethyl acetate
  3. customto stand at room temperature
  4. customThe crystals which precipitated
  5. filtrationwere collected by filtration
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-8b2ae6e0ac0849c1932b18db575dcc8b
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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