Propargyl bromide → Propargyl ether

HRID 743416

반응식

HRID 743416 반응식
[F:1][C:2]([F:23])([F:22])[C:3]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)([C:11]([F:14])([F:13])[F:12])[C:4]1[CH:10]=[CH:9][C:7]([OH:8])=[CH:6][CH:5]=1.[CH2:24](Br)[C:25]#[CH:26].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:26]([O:21][CH2:18][C:19]#[CH:20])[C:25]#[CH:24].[F:1][C:2]([F:22])([F:23])[C:3]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)([C:11]([F:13])([F:14])[F:12])[C:4]1[CH:10]=[CH:9][C:7]([OH:8])=[CH:6][CH:5]=1

참가 물질

6

반응물 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 73864bisphenol AF

생성물 2

HCID 23349Propargyl etherHCID 73864bisphenol AF

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A solution of 168.12 g. (0.5 mole) of hexafluorobisphenol A in 1000 ml of acetone was reacted with 142.76 g. (1.2 moles) of propargyl bromide in the presence of 165.85 g. (1.2 moles) of potassium carbonate. The reaction mixture was stirred and heated under reflux for 72 hrs. After cooling it was filtered and the solvent (acetone) of the filtrate was evaporated on a Buchi Re 121 Rotavapor. The residue was dissolved in diethyl ether and washed first with a 5% NaOH solution and then three times with deionized water. Dipropargyl ether of hexafluorobisphenol A was obtained in 90% yield after evaporation of diethyl ether on a Rotavapor. The product was a light brown liquid with the following structure. ##STR11##

후처리

  1. temperatureheated
  2. temperatureunder reflux for 72 hrs
  3. temperatureAfter cooling it
  4. filtrationwas filtered
  5. customthe solvent (acetone) of the filtrate was evaporated on a Buchi Re 121 Rotavapor
  6. dissolutionThe residue was dissolved in diethyl ether
  7. washwashed first with a 5% NaOH solution

출처 및 근거

ORD 기록
ord-57033bdd4c22439aaf34b4eca7fcf324
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556921

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