Sodium Hydroxide → 2-(1H-1,2,3,4-tetrazol-5-yl)benzoic acid

HRID 743883노트

반응식

HRID 743883 반응식
[N:1]1[NH:2][N:3]=[N:4][C:5]=1[C:6]1[CH:16]=[CH:15][CH:14]=[CH:13][C:7]=1[C:8]([O:10]CC)=[O:9].[OH-].[Na+]>C(O)C>[N:4]1[NH:3][N:2]=[N:1][C:5]=1[C:6]1[CH:16]=[CH:15][CH:14]=[CH:13][C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 583755ethyl 2-(2H-tetrazol-5-yl)benzoate

생성물 1

HCID 5551922-(1H-1,2,3,4-tetrazol-5-yl)benzoic acid수율 0.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Methyl 2-cyanobenzoate (0.124 moles, 20.0 g) was dissolved in 55 g tributyltinazide and heated at 85° C. for 72 hours. The solution was allowed to cool. Methanol (200 mi) and water (50 mi) were added. The solution was stirred for 1hour. Ethyl acetate and brine were added. The organic layer was dried and evaporated. The residue was triturated 3 times with large volumes of hexane, dissolved in chloroform, and precipitated with hexane. The precipitate was filtered to yield 10.0 g of ethyl 2-(2H-tetrazol-5-yl)benzoate. The ester (6.8 moles, 1.4 g) was dissolved in 5 ml ethanol and 10 ml of 2N NaOH added and heated on a steam bath for 1 hour. The solvent was removed under vacuum. The residue was dissolved in water. The pH was adjusted to 2.0 using 2N HCl. The intermediate was extracted with ethyl acetate to yield 0.8 g of 2-(2-H-tetrazol-5-yl)benzoic acid.

후처리

  1. temperatureheated on a steam bath for 1 hour
  2. customThe solvent was removed under vacuum
  3. dissolutionThe residue was dissolved in water
  4. extractionThe intermediate was extracted with ethyl acetate

출처 및 근거

ORD 기록
ord-0f7c710dd9434417a7bc8b5aca7bd4b5
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556981

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