Hydrogen chloride-ethyl acetate → 1-{3-[2-(1-Benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride

HRID 7439

반응식

HRID 7439 반응식
[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.C(OCC)(=O)C.[ClH:27]>C(OCC)(=O)C>[ClH:27].[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:17][CH:18]([OH:20])[CH2:19]3)[CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 235455641-(3-(2-(1-Benzothiophene-6-yl)ethoxy)propyl)-3-azetidinol

생성물 1

HCID 665884131-{3-[2-(1-Benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

In 3.0 mL of ethyl acetate was dissolved 0.28 g of 1-{3-[2-(1-benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol, and to the solution was added 0.35 mL of a 3.25 mol/L dried hydrogen chloride-ethyl acetate solution, after which the resulting mixture was stirred at room temperature for 1 hour. Then, the solvent was distilled off under reduced pressure to obtain 0.30 g of 1-{3-[2-(1-benzothiophen-6-yl)ethoxy]propyl}-3-azetidinol hydrochloride as a light-yellow oil.

후처리

  1. distillationThen, the solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-8299922f87304667a70416c850fe5f40
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087594B2

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