Ethanol → 4-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole

HRID 744719노트

반응식

HRID 744719 반응식
C([N:8]1[C:12]([C:13]([OH:37])([C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[CH:26][CH:25]=2)[CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1.C(O)C.C([O-])=O.[NH4+]>[Pd].O>[F:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][CH2:15][CH2:14][C:13]([C:12]2[N:8]=[CH:9][NH:10][CH:11]=2)([OH:37])[C:24]2[CH:29]=[CH:28][C:27]([C:30]([NH:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:31])=[CH:26][CH:25]=2)=[CH:18][CH:19]=1

참가 물질

6

반응물 3

HCID 702EthanolHCID 2723923Ammonium formateHCID 194219951-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1-H-imidazole

생성물 1

HCID 1784493104-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1H-imidazole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

12,95 g of 1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxy-1-(4-tert-butylaminocarbonylphenyl)butyl]-1-H-imidazole is dissolved into ethanol (400 ml) and water (130 ml). 8,17 g of ammonium formate and 1,3 g of 10% Pd/C is added to the solution and the mixture is refluxed for three hours. Then the reaction mixture is filtered through siliceous earth and the flitrate is evaporated to dryness. The residue is dissolved into ethyl acetate, washed with 2M aqueous sodium hydroxide and water, dried and evaporated to dryness.

후처리

  1. temperaturethe mixture is refluxed for three hours
  2. filtrationThen the reaction mixture is filtered through siliceous earth
  3. customthe flitrate is evaporated to dryness
  4. dissolutionThe residue is dissolved into ethyl acetate
  5. washwashed with 2M aqueous sodium hydroxide and water
  6. customdried
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f491f2ceab98476cbd872f0c8094d752
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559141

반응 노트

불러오는 중…