Methyl iodide → 2-Methoxyphenethyl alcohol
반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][OH:10].[C:11]([O-])([O-])=O.[Cs+].[Cs+].CI>CC(C)=O>[OH:10][CH2:9][CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH3:11]참가 물질
5
실험 절차
To a solution of 10 g of 2-(2-hydroxyphenyl)-ethanol in 200 ml of acetone there are added 35.3 g of Cs2CO3 and then a solution of 6.5 ml of methyl iodide in 40 ml of acetone. The reaction mixture is stirred for 50 minutes at room temperature, is filtered and is concentrated by evaporation. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation, and the residue is purified by means of FC (dichloromethane/diethyl ether=97:3), yielding the title compound: Rf (dichloromethane/diethyl ether=97:3)=0.34; HPLC Rt =9.31 minutes.
후처리
- filtrationis filtered
- concentrationis concentrated by evaporation
- customThe residue is partitioned between diethyl ether and water
- dry with materialdried over magnesium sulfate
- concentrationconcentrated by evaporation
- customthe residue is purified by means of FC (dichloromethane/diethyl ether=97:3)
출처 및 근거
- ORD 기록
- ord-72e2939e43e84e3faff273817dad7307
- 출처 데이터셋
- uspto-grants-1996_09
- 특허 번호
- US05559111
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