Bromotrimethylsilane → 4-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene

HRID 744837노트

반응식

HRID 744837 반응식
C[Si](C)(C)[Br:3].[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12]O)=[CH:10][C:9]=1[O:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21]>C(Cl)(Cl)Cl>[CH3:6][O:7][C:8]1[CH:15]=[CH:14][C:11]([CH2:12][Br:3])=[CH:10][C:9]=1[O:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21]

참가 물질

4

반응물 2

HCID 76113BromotrimethylsilaneHCID 451081634-Methoxy-3-(3-methoxypropoxy)benzenemethanol

생성물 1

HCID 115583294-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

97 ml of trimethylbromosilane are added, with stirring at room temperature, to 113.1 g of 4-methoxy-3-(3-methoxypropyloxy)-benzyl alcohol in 1.31 liters of chloroform. After 10 minutes the solvent is evaporated off and the residue is immediately purified by means of FC (900 g of silica gel, eluant: ethyl acetate/hexane 1:3). The title compound is obtained: Rf (ethyl acetate/hexane=1:2)=0.34; m.p. 50°-51 ° C.

후처리

  1. customAfter 10 minutes the solvent is evaporated off
  2. customthe residue is immediately purified by means of FC (900 g of silica gel, eluant: ethyl acetate/hexane 1:3)

출처 및 근거

ORD 기록
ord-48b8e3e3e759429d9f51f929a8ec8fb3
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559111

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