Potassium Carbonate → 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol

HRID 744838

반응식

HRID 744838 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH3:11])[CH2:5][OH:6].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][CH2:20][CH2:21][O:22][CH3:23].C(OCC)(=O)C.CCCCCC>CC(C)=O>[CH3:11][O:10][C:9]1[CH:8]=[CH:7][C:4]([CH2:5][OH:6])=[CH:3][C:2]=1[O:1][CH2:19][CH2:20][CH2:21][O:22][CH3:23]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 780893-Hydroxy-4-methoxybenzyl alcoholHCID 5245511-Bromo-3-methoxypropaneHCID 21226206Ethyl acetate hexane

생성물 1

HCID 451081634-Methoxy-3-(3-methoxypropoxy)benzenemethanol

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

7.7 g of 3-hydroxy-4-methoxy-benzyl alcohol, 10.35 g of potassium carbonate and 12.1 g of 1-bromo-3-methoxy-propane are stirred under reflux in 150 ml of acetone for 3 days. After evaporation of the solvent, water is added to the residue and extraction is carried out with ethyl acetate. After evaporation of the solvent the title compound is obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4): Rf (ethyl acetate/hexane=2:1)=0.31.

후처리

  1. customAfter evaporation of the solvent, water
  2. additionis added to the residue and extraction
  3. customAfter evaporation of the solvent the title compound
  4. customis obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4)

출처 및 근거

ORD 기록
ord-90987c5053f4457cbdcb4e6353323a94
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559111

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