Benzylamine → 1-[(Benzylcarbamoyl)oxy]pyrrolidine-2,5-dione

HRID 744899노트

반응식

HRID 744899 반응식
C1C(=O)N(O[C:9]([O:11][N:12]2[C:17](=[O:18])[CH2:16][CH2:15][C:13]2=[O:14])=[O:10])C(=O)C1.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[CH2:19]([NH:26][C:9](=[O:10])[O:11][N:12]1[C:13](=[O:14])[CH2:15][CH2:16][C:17]1=[O:18])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 676246Di(succinimido) carbonate

생성물 1

HCID 131119021-[(Benzylcarbamoyl)oxy]pyrrolidine-2,5-dione수율 76.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

18.4 g of N,N'-disuccinimidyl carbonate are added in small portions at 5° C. within 5 minutes to a solution of 6.4 g of benzylamine in 150 ml of acetonitrile. The reaction mixture is stirred at room temperature and then evaporated. The residue is taken up in ethyl acetate and washed with water. The organic phase is dried, concentrated and the residue is recrystallized from methylene chlorideohexane. 11.3 g of colourless 2,5-dioxo-pyrrolidin-1-yl benzylcarbamate, MS (FAB): 133 (M- HO-Succ), are isolated.

후처리

  1. customevaporated
  2. washwashed with water
  3. customThe organic phase is dried
  4. concentrationconcentrated
  5. customthe residue is recrystallized from methylene chlorideohexane

출처 및 근거

ORD 기록
ord-b9bf4828c6d94554ac084721824d2361
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559232

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