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Triethylamine → (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone

HRID 74508
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인쇄 미리보기

반응식

HRID 74508 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.[Cl:11][C:12]1[CH:13]=[C:14]([CH:18]=[CH:19][N:20]=1)[C:15](O)=[O:16].C(N(CC)CC)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[Cl:11][C:12]1[CH:13]=[C:14]([C:15]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)[CH2:5][CH2:6]2)=[O:16])[CH:18]=[CH:19][N:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 2369852-Chloroisonicotinic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27744635-Fluoroindoline

생성물 1

HCID 58386590(2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 198 mg (1.26 mmol) 2-chloroisonicotinic acid, 351 μL (2.50 mmol) triethylamine and 434 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.

후처리

  1. customPurification
  2. customevaporated down i

출처 및 근거

ORD 기록
ord-5d720ad4a5af4249b03846e9b4bcd2f1
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08829006B2

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