Hydrochloric Acid → N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

HRID 745175노트

반응식

HRID 745175 반응식
[Cl:1][CH2:2][CH2:3][S:4]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])=[O:5].[CH:14]([NH2:17])([CH3:16])[CH3:15].Cl.CCOCC>CO>[ClH:1].[C:8]1([CH2:7][S:4]([CH2:3][CH2:2][NH:17][CH:14]([CH3:16])[CH3:15])(=[O:6])=[O:5])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 6363IsopropylamineHCID 99230(((2-Chloroethyl)sulfonyl)methyl)benzene

생성물 1

HCID 13655079N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride수율 65.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was partitioned between ether and dilute sodium hydroxide
  3. dry with materialThe ether solution was dried over magnesium sulfate
  4. customthe solvent was removed in vacuo
  5. customto give an oil
  6. customa white solid precipitated

출처 및 근거

ORD 기록
ord-4c828b8a9bbe475787be2847289c49cf
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04597902

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