Hydrochloric Acid → N'-Phenylcyclobutanecarbohydrazide

HRID 74518노트

반응식

HRID 74518 반응식
[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[C:8]1([NH:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.N1C=CC=CC=1.Cl>CN(C=O)C>[C:8]1([NH:14][NH:15][C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[O:6])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 7516PhenylhydrazineHCID 78705Cyclobutanecarbonyl chloride

생성물 1

HCID 13728291N'-Phenylcyclobutanecarbohydrazide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

3.54 mL (31.0 mmol) cyclobutanecarboxylic acid chloride were added dropwise at RT to 3.00 mL (30.2 mmol) phenylhydrazine and 4.75 mL (60.0 mmol) pyridine in 30 mL DMF. The mixture was stirred for 1 h at RT and poured onto 200 mL of a 1M hydrochloric acid solution. The precipitated solid was suction filtered, washed with 50 mL water and dried i. vac. The product was extracted with 50 mL ether and suction filtered. The solid was washed with 20 mL ether and dried in the air.

후처리

  1. filtrationfiltered
  2. washwashed with 50 mL water
  3. customdried i
  4. extractionThe product was extracted with 50 mL ether and suction
  5. filtrationfiltered
  6. washThe solid was washed with 20 mL ether
  7. customdried in the air

출처 및 근거

ORD 기록
ord-751690bac2704318a4bd743d93e918ee
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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