Hydrochloric Acid → N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

HRID 745213

반응식

HRID 745213 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:15](=[O:16])[CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]2[C:7]1=[O:8].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(=O)([O-])[O-].[K+].[K+].[ClH:35]>CN(C)C=O>[ClH:35].[N:17]1[CH:22]=[CH:21][CH:20]=[N:19][C:18]=1[N:23]1[CH2:28][CH2:27][N:26]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:15](=[O:16])[CH:10]3[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]3[C:7]2=[O:8])[CH2:25][CH2:24]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 887471-(2-Pyrimidinyl)piperazineHCID 13671565N-(4-bromobutyl)cyclohexane-1,2-dicarboximide

생성물 1

HCID 23315240N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of N-(4-bromobutyl)cyclohexane-1,2-dicarboximide (10.00 g), 1-(2-pyrimidyl)piperazine (4.75 g), anhydrous potassium carbonate powder (8.00 g) and anhydrous dimethylformamide (100 ml) was stirred at 100°-110° C. for 9 hours. The solvent was removed from the reaction mixture under reduced pressure, and the residue was purified by chromatography to give an oily substance, which was then treated with hydrogen chloride to give N-[4-{4-(2-pyrimidinyl)-1-piperazinyl}butyl]cyclohexane-1,2-dicarboximide hydrochloride. M.P., 168°-169° C.

후처리

  1. customThe solvent was removed from the reaction mixture under reduced pressure
  2. customthe residue was purified by chromatography
  3. customto give an oily substance, which

출처 및 근거

ORD 기록
ord-6b35f752576b44fe9eb2069991caa63c
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04598078

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