Malonic Acid → 3-Amino-3-(4-methylphenyl)propanoic acid

HRID 745248노트

반응식

HRID 745248 반응식
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[C:10]([OH:16])(=[O:15])[CH2:11]C(O)=O.C([O-])(=O)C.[NH4+:21]>C(O)C>[NH2:21][CH:7]([C:4]1[CH:5]=[CH:6][C:1]([CH3:9])=[CH:2][CH:3]=1)[CH2:11][C:10]([OH:16])=[O:15]

참가 물질

5

반응물 3

HCID 867Malonic AcidHCID 77254-MethylbenzaldehydeHCID 517165Ammonium Acetate

생성물 1

HCID 27336803-Amino-3-(4-methylphenyl)propanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 10 ml of p-tolualdehyde, were added 180 ml of ethanol, 9.8 g of malonic acid, and 15.8 g of ammonium acetate. The mixture was refluxed for 5 hours. After cooling, the insolubles were removed by filtration. After addition of 100 ml of water, the filtrate was adjusted to pH 7.0 with 1N hydrochloric acid, and the precipitated crystals were collected by filtration to yield 5.4 g of β-amino-β-(4-methylphenyl)propionic acid; m.p. 228°-229° C.

후처리

  1. temperatureThe mixture was refluxed for 5 hours
  2. temperatureAfter cooling
  3. customthe insolubles were removed by filtration
  4. additionAfter addition of 100 ml of water
  5. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-75f73cb4a52a49e8913c11d472063eb0
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04598077

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