Benzylamine → Benzyl-(2,2,2-trifluoro-ethyl)-amine

HRID 74527

반응식

HRID 74527 반응식
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:21][CH2:3][C:2]([F:13])([F:12])[F:1])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

생성물 1

HCID 4962181Benzyl-(2,2,2-trifluoro-ethyl)-amine

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

2.17 g (9.4 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.00 g (18.7 mmol) benzylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the reaction mixture was suction filtered, washed with DIPE and the filtrate was evaporated down using the rotary evaporator. The residue was purified by flash chromatography. The product fractions were combined and evaporated down using the rotary evaporator.

후처리

  1. temperaturethe reaction mixture was refluxed overnight
  2. temperatureAfter cooling the reaction mixture
  3. filtrationfiltered
  4. washwashed with DIPE
  5. customthe filtrate was evaporated down
  6. customthe rotary evaporator
  7. customThe residue was purified by flash chromatography
  8. customevaporated
  9. customthe rotary evaporator

출처 및 근거

ORD 기록
ord-12297a9fd6ac4c479c6a214c31118f3c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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