Triethylamine → HCID 58386575, 화합물

HRID 74530

반응식

HRID 74530 반응식
CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[O:23]=[C:24]1[NH:32][C:27]2=[N:28][CH:29]=[CH:30][CH:31]=[C:26]2[N:25]1[CH:33]1[CH2:38][CH2:37][N:36]([C:39]2[N:44]=[CH:43][N:42]=[C:41]([C:45]([OH:47])=O)[CH:40]=2)[CH2:35][CH2:34]1.[N+:48]([C:51]1[CH:52]=[C:53]2[C:57](=[CH:58][CH:59]=1)[NH:56][CH2:55][CH2:54]2)([O-:50])=[O:49].C(N(CC)CC)C>CN(C=O)C.O>[N+:48]([C:51]1[CH:52]=[C:53]2[C:57](=[CH:58][CH:59]=1)[N:56]([C:45]([C:41]1[N:42]=[CH:43][N:44]=[C:39]([N:36]3[CH2:37][CH2:38][CH:33]([N:25]4[C:26]5[C:27](=[N:28][CH:29]=[CH:30][CH:31]=5)[NH:32][C:24]4=[O:23])[CH2:34][CH2:35]3)[CH:40]=1)=[O:47])[CH2:55][CH2:54]2)([O-:50])=[O:49]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 362195-NitroindolineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 583866966-[4-(2-Oxo-2,3-dihydroimidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]pyrimidine-4-carboxylic acid

생성물 1

HCID 58386575HCID 58386575, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

150 mg (0.47 mmol) TBTU were added to 150 mg (0.44 mmol) 6-[4-(2-oxo-2,3-dihydro-imidazo[4,5-b]pyridin-1-yl)-piperidin-1-yl]-pyrimidine-4-carboxylic acid, 75 mg (0.46 mmol) 5-nitro-2,3-dihydro-1H-indole, 100 μL and (0.712 mmol) triethylamine in 1.5 mL DMF and the mixture was stirred overnight at RT. The reaction mixture was poured onto 30 mL water. The precipitated product was suction filtered and dried at 50° C. in the CAD.

후처리

  1. filtrationfiltered
  2. customdried at 50° C. in the CAD

출처 및 근거

ORD 기록
ord-82f55e6c994141e0a18f1092baf0e473
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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