Ethanolamine → 3-(2-Aminoethoxy)-6-chloropyridazine hydrochloride

HRID 745502노트

반응식

HRID 745502 반응식
[H-].[Na+].[NH2:3][CH2:4][CH2:5][OH:6].[Cl:7][C:8]1[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=1>C1C=CC=CC=1>[ClH:7].[NH2:3][CH2:4][CH2:5][O:6][C:11]1[N:10]=[N:9][C:8]([Cl:7])=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 700EthanolamineHCID 24758Sodium hydrideHCID 673313,6-Dichloropyridazine

생성물 1

HCID 233135663-(2-Aminoethoxy)-6-chloropyridazine hydrochloride수율 54.2%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a suspension of 4.2 g of 61% sodium hydride in 100 ml of benzene was added dropwise 6.2 g of 2-aminoethanol at room temperature. Then, 15 g of 3,6-dichloropyridazine was added, and the mixture was refluxed for 1 hour. After cooling, the reaction mixture was washed with water, and dried over magnesium sulfate. After evaporating the solvent, the residue was treated with hydrogen chrolide-ether solution to give 5.73 g of 3-(2-aminoethoxy)-6-chloropyridazine hydrochloride as crystals.

후처리

  1. temperaturethe mixture was refluxed for 1 hour
  2. temperatureAfter cooling
  3. washthe reaction mixture was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customAfter evaporating the solvent
  6. additionthe residue was treated with hydrogen chrolide-ether solution

출처 및 근거

ORD 기록
ord-5c6ef1edb3be4f9d8326bfb04e2e20ab
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599333

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