Hydrochloric Acid → 2-Propanol, 1-[(2-amino-1,1-dimethylethyl)amino]-3-(2-methylphenoxy)-

HRID 745508노트

반응식

HRID 745508 반응식
Cl.[CH3:2][C:3]1[CH:33]=[CH:32][CH:31]=[CH:30][C:4]=1[O:5][CH2:6][CH:7]([OH:29])[CH2:8][NH:9][C:10]([CH3:28])([CH3:27])[CH2:11][N:12](CC1C=CC=CC=1)CC1C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:2][C:3]1[CH:33]=[CH:32][CH:31]=[CH:30][C:4]=1[O:5][CH2:6][CH:7]([OH:29])[CH2:8][NH:9][C:10]([CH3:28])([CH3:27])[CH2:11][NH2:12]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 537951651-(2-Methylphenoxy)-3-(1,1-dimethyl-2-dibenzylaminoethylamino)-2-propanol

생성물 1

HCID 100607882-Propanol, 1-[(2-amino-1,1-dimethylethyl)amino]-3-(2-methylphenoxy)-수율 90.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

Concentrated hydrochloric acid (1.4 ml) and 5% palladium carbon was added to a solution of 3 g of 1-(2-methylphenoxy)-3-(1,1-dimethyl-2-dibenzylaminoethylamino)-2-propanol in 10 ml of ethanol, and the mixture was hydrogenated at room temperature for 24 hours. After the catalyst was removed by filtration, the filtrate was concentrated under reduced pressure. The residue was dissolved in water, made alkaline with potassium carbonate, then extracted with chloroform, and dried over anhydrous magnesium sulfate. 1.585 g of 1-(2-methylphenoxy)-3-(1,1-dimethyl-2-aminoethylamino)-2-propanol was obtained as a colorless oil.

후처리

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted with chloroform
  5. dry with materialdried over anhydrous magnesium sulfate

출처 및 근거

ORD 기록
ord-1c53379146c742659cfdfcc3488143c6
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599333

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