Dichloromethane → 2-Methylene-3-quinuclidone

HRID 745539

반응식

HRID 745539 반응식
Cl.O.O.[CH2:4]=[C:5]1[C:10](=[O:11])[CH:9]2[CH2:12][CH2:13][N:6]1[CH2:7][CH2:8]2.C(=O)([O-])[O-].[K+].[K+].C(Cl)Cl>O>[CH2:4]=[C:5]1[C:10](=[O:11])[CH:9]2[CH2:12][CH2:13][N:6]1[CH2:7][CH2:8]2

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 219542752-Methylene-3-quinuclidinone dihydrate hydrochloride

생성물 1

HCID 3229732-Methylene-3-quinuclidone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Suspend 95.4 g (0.455 mole) 2-methylene-3-quinuclidinone dihydrate hydrochloride in a solution of 255 g (1.85 moles) anhydrous potassium carbonate dissolved in 350 ml H2O. When the suspension clears add 500 ml methylene chloride and mix the 2-phase system overnight using a mechanical stirrer. Separate the layers and dry the methylene chloride layer over potassium carbonate. Remove the solvents in vacuo to obtain the title compound. Repeat the extraction until most of the product is collected.

후처리

  1. additionmix the 2-phase system overnight
  2. customSeparate the layers
  3. dry with materialdry the methylene chloride layer over potassium carbonate
  4. customRemove the solvents in vacuo

출처 및 근거

ORD 기록
ord-8487bf1433834c318e8cfa3a4af4c32e
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599344

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