Ammonia → HCID 58386658, 화합물

HRID 74555

반응식

HRID 74555 반응식
Br[C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][CH:14]([N:17]2[C:25]3[C:20](=[N:21][CH:22]=[CH:23][CH:24]=3)[NH:19][C:18]2=[O:26])[CH2:13][CH2:12]1.N>O>[O:26]=[C:18]1[NH:19][C:20]2=[N:21][CH:22]=[CH:23][CH:24]=[C:25]2[N:17]1[CH:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=2)[CH2:12][CH2:13]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 2227012-Bromoisonicotinic acidHCID 22293182Bms-973013

생성물 1

HCID 58386658HCID 58386658, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.50 g (2.4 mmol) 2-bromopyridine-4-carboxylic acid and 1.1 g (5.0 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one were mixed and melted for 10 min using the hot air blower. The reaction mixture was cooled, mixed with water and made basic with ammonia. It was extracted with EtOAc. The aqueous phase was concentrated and purified by HPLC. The product-containing fractions were combined and concentrated to dryness by rotary evaporation.

후처리

  1. temperatureThe reaction mixture was cooled
  2. extractionIt was extracted with EtOAc
  3. concentrationThe aqueous phase was concentrated
  4. custompurified by HPLC
  5. concentrationconcentrated to dryness by rotary evaporation

출처 및 근거

ORD 기록
ord-d9b8229d44f84c40bdf10d0071e87ef6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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