p-Fluorotoluene → 4-Fluorobenzyl bromide

HRID 745631

반응식

HRID 745631 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.C1C(=O)N([Br:16])C(=O)C1>C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.C(Cl)(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Br:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 9603p-FluorotolueneHCID 67184N-bromobutanimide

생성물 1

HCID 680214-Fluorobenzyl bromide수율 101.1%

시약·촉매·용매 2

HCID 7187Benzoyl Peroxide촉매HCID 5943Carbon Tetrachloride용매

실험 절차

A 300-ml flask was charged with 16.6 g of 4-fluorotoluene, 30.0 g of NBS, 0.5 g of benzoyl peroxide and 150 ml of carbon tetrachloride, and the mixture was refluxed for 2.0 hours. The reaction mixture was cooled to room temperature, and the formed precipitate was removed by filtration and the residual CCl4 solution was washed with dilute alkali and then with water, dried over Na2SO4, and evaporated under reduced pressure to give 28.8 g of crude 4-fluorobenzyl bromide.

후처리

  1. temperaturethe mixture was refluxed for 2.0 hours
  2. customthe formed precipitate was removed by filtration
  3. washthe residual CCl4 solution was washed with dilute alkali
  4. dry with materialwith water, dried over Na2SO4
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5a691619f9e84ad28f0c0874349bf589
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599362

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