Triethylsilane → methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate

HRID 74572

반응식

HRID 74572 반응식
C([SiH](CC)CC)C.[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[C:13]([C:20](=O)[C:21]([O:23][CH3:24])=[O:22])=[CH:14][NH:15]2)([O-:10])=[O:9]>FC(F)(F)C(O)=O>[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH2:14][NH:15]2)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 12052TriethylsilaneHCID 10243717Methyl (4-nitro-1H-indol-3-yl)(oxo)acetate

생성물 1

HCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Under an argon atmosphere 16 mL (0.10 mmol) triethylsilane were slowly added dropwise to 2.3 g (9.3 mmol) methyl (4-nitro-1H-indol-3-yl)-oxo-acetate in 18 mL trifluoroacetic acid while cooling with ice. Then the mixture was stirred for a further 3 h at RT and evaporated down. The residue was dried and then triturated with diisopropylether, suction filtered and dried in the air.

후처리

  1. temperaturewhile cooling with ice
  2. customevaporated down
  3. customThe residue was dried
  4. customtriturated with diisopropylether, suction
  5. filtrationfiltered
  6. customdried in the air

출처 및 근거

ORD 기록
ord-4dc15c7d857a4497b86d2906e813aebc
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

연결된 노트

불러오는 중…