Triethylsilane → methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate
반응식
C([SiH](CC)CC)C.[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[C:13]([C:20](=O)[C:21]([O:23][CH3:24])=[O:22])=[CH:14][NH:15]2)([O-:10])=[O:9]>FC(F)(F)C(O)=O>[N+:8]([C:11]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:12]=1[CH:13]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH2:14][NH:15]2)([O-:10])=[O:9]참가 물질
4
실험 절차
Under an argon atmosphere 16 mL (0.10 mmol) triethylsilane were slowly added dropwise to 2.3 g (9.3 mmol) methyl (4-nitro-1H-indol-3-yl)-oxo-acetate in 18 mL trifluoroacetic acid while cooling with ice. Then the mixture was stirred for a further 3 h at RT and evaporated down. The residue was dried and then triturated with diisopropylether, suction filtered and dried in the air.
후처리
- temperaturewhile cooling with ice
- customevaporated down
- customThe residue was dried
- customtriturated with diisopropylether, suction
- filtrationfiltered
- customdried in the air
출처 및 근거
- ORD 기록
- ord-4dc15c7d857a4497b86d2906e813aebc
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08829006B2
반응 노트
불러오는 중…