Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 745741노트

반응식

HRID 745741 반응식
C(N)CCCCCCCCCCCCCCCC.[CH:19]1([N:25]=[C:26]=[N:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1.N(C(OC(C)(C)C)=O)(CC(O)=[O:38])C>C(Cl)(Cl)Cl>[C:26]([NH:25][CH:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1)([NH:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1)=[O:38]

참가 물질

5

반응물 3

HCID 10868Dicyclohexylcarbodiimide2회HCID 15791HeptadecylamineHCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-

생성물 1

HCID 4277N,N'-Dicyclohexylurea

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

C17BocSar1 : the product C17BocSar1 is obtained by coupling heptadecylamine with BocSar1 in the presence of dicyclohexylcarbodiimide (DCCI). 3.78 g (0.02 mole) of BocSar and 2.06 g (0.01 mole) of DCCI are mixed cold (at 0° C.) in 100 ml of chloroform. A copious precipitate of dicyclohexylurea (DCU) is formed. The mixture is left for 30 minutes at 0° C., with agitation, and 2.55 g (0.01 mole) of heptadecylamine are added. The reaction is left to proceed for 20 hours. The precipitate is filtered off and washed, the filtrate is recovered, the chloroform is evaporated off, the residue is taken up in 50 ml of THF, the mixture is cooled to 0° C. and filtered to remove the maximum amount of dicyclohexylurea, and the precipitate is washed with the minimum amount of cold THF.

후처리

  1. customC17BocSar1 : the product C17BocSar1 is obtained

출처 및 근거

ORD 기록
ord-65d3e44c71d54ad39804d2efbd1b4efc
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04600526

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