Maleic Anhydride → Fluorescein maleamic acid

HRID 745848

반응식

HRID 745848 반응식
[CH:1]1[C:6]([NH2:7])=[CH:5][C:4]2[C:8]([O:10][C:11]3([C:21]4[CH:22]=[CH:23][C:24]([OH:26])=[CH:25][C:20]=4[O:19][C:13]4[CH:14]=[C:15]([OH:18])[CH:16]=[CH:17][C:12]3=4)[C:3]=2[CH:2]=1)=[O:9].[C:27]1(=[O:33])[O:32][C:30](=[O:31])[CH:29]=[CH:28]1>C(O)(=O)C>[CH:1]1[CH:6]=[CH:5][C:4]([C:8]([OH:10])=[O:9])=[C:3]([C:11]2[C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=3[O:19][C:20]3[C:21]=2[CH:22]=[CH:23][C:24]([CH:25]=3)=[O:26])[CH:2]=1.[C:27]([OH:32])(=[O:33])/[CH:28]=[CH:29]\[C:30]([NH2:7])=[O:31]

참가 물질

4

반응물 2

HCID 7923Maleic AnhydrideHCID 768455-Aminofluorescein

생성물 1

HCID 131714782Fluorescein maleamic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 350 milligrams (0.001 mols) of 5-aminofluorescein and 300 milligrams (excess) of maleic anhydride were mixed in 5.0 milliliters of glacial acetic acid and the mixture was stirred at ambient temperature for 24 hours. The yellow product formed was filtered off and washed three times with diethyl ether. 420 Milligrams of fluorescein-maleamic acid was obtained. 1.R (KBR) showed bands at 2.55; 3.28; 3.38; 4.05; 5.85; 6.30; 6.52; 6.88; 6.90; 7.70; 8.34; 8.52; and 8.30μ.

후처리

  1. customThe yellow product formed
  2. filtrationwas filtered off
  3. washwashed three times with diethyl ether

출처 및 근거

ORD 기록
ord-ec89bd94355a4786b06c363daa5e8ec9
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04600775

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