5-Aminofluorescein (HCID 76845)

개요

5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It is functionally related to a fluorescein (lactone form).

이름 및 식별자

우선 이름: 5-Aminofluorescein
IUPAC: 6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
현지명: 5-아미노플루오레세인
영어명: 5-Aminofluorescein
분자식: C20H13NO5
분자량: 347.32

이름 및 동의어

5-Aminofluorescein3326-34-95-fluoresceinamineSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-YY8M286SWUDTXSID0062979CHEBI:91078Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 5-amino-3',6'-dihydroxy-RefChem:532426DTXCID1038660222-043-6Fluoresceinamine

이름 더 보기

5-아미노플루오레세인5-AFAMINOFLUORESCEIN4-AMINOFLUORESCEIN5-AMF(isoMer I)1-FLUORESCEINAMINE

Fluoresceinamine Isomer IFluoresceinamine, isomer IFluoresceinamine, isomer 15-AFMMFCD00005052fluorescein-5-amine6-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one5-amino-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one

데이터베이스 식별자

CAS: 3326-34-9
PubChem CID: 76845
DTXSID: DTXSID0062979
ChEMBL: CHEMBL5284644
ChEBI: CHEBI:91078
UNII: YY8M286SWU
EC Number: 222-043-6
Nikkaji: J205.409D

물성

구조 계산 물성

XLogP: 2.7
극성 표면적: 102 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 6
회전 가능 결합 수: 0
무거운 원자 수: 26
형식 전하: 0
복잡도: 557

실험 및 물리화학적 성질

Endocrine DisruptorsPotential endocrine disrupting compound

물리화학적 성질

녹는점: 223 °C · 223 °C (dec.)(lit.)
끓는 점: 481.89 °C · 481.89°C (rough estimate)
밀도: 1.3724 · 1.3724 (rough estimate)
굴절률: 1.518 · 1.5180 (estimate)
저장 조건: room temp
용해도: 5 mg/ml; · DMF: 5 mg/ml; DMSO: 5 mg/ml
산도 계수 (pKa): 9.34 · 9.34±0.20(Predicted)
물리적 상태: 가루
색상: 적갈색
수용성: 물(일부), 메탄올(10mg/ml) 및 아세톤에 용해됩니다.
BRN: 48395 · 48395
안정성: 빛과 습기에 민감함
주요 응용: 진단 검사 제조혈액학조직학
InChI: 1S/C20H13NO5/c21-10-1-4-14-13(7-10)19(24)26-20(14)15-5-2-11(22)8-17(15)25-18-9-12(23)3-6-16(18)20/h1-9,22-23H,21H2
InChIKey: GZAJOEGTZDUSKS-UHFFFAOYSA-N
SMILES: Nc1ccc2c(c1)C(=O)OC23c4ccc(O)cc4Oc5cc(O)ccc35
EPA: -1 · Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy- (3326-34-9)

화학적 성질

Dark Red Solid

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (98.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 85 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (98.8%)

안전 데이터

wgk: 3
tsca: TSCA listed
HS 번호: 32049090
risk_code: 22-36/37/38
hazard_code: Xn
safety_code: 26
F 고인화성물질: 10
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

용도 및 제조

General Manufacturing InformationSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-: ACTIVE

응용 분야

용도Glycosaminoglycuronans react with 5-aminofluorescein to yield fluorescent derivatives. 5-aminofluorescein is also used to prepare FITC Isomer I (F-011, F-020).

일반 설명Fluoresceinamine, isomer I belongs to the class of derivatized fluoresceins.

제조 방법 · 1건

The preparation of 5-aminofluorescein is carried out either by first saponification of 5-nitrofluorescein acetates with alcohol alkali, followed by reduction of the obtained 5-nitrofluorescein in a solution of alcohol alkali with hydrazine hydrate on a nickel catalyst to obtain 5-aminofluorescein , Or by boiling in an aqueous solution of sodium sulfide. The restoration of the nitro group and the saponification of acetates in the second case occurs in one stage.

상·하류 제품 정보

상류 원료

하류 제품

Fluorescein isothiocyanate 아지도플루오레세인

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

成都彼样生物科技有限公司18108052721 · [email protected]

VladaChem GmbH+49-7246-3082843 +86-18411632868 · [email protected]

추가 설명 · 1건

정의ChEBI: 5-aminofluorescein is a primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid. It derives from a fluorescein (lactone form).