Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole → 1-(Phenylsulfonyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole | HCID 798 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(Phenylsulfonyl)-1H-indole | HCID 315017 | — |
반응 단계
0.89 g (22 mmol) sodium hydride (60%) were added to 2.0 g (17 mmol) indole in 30 mL THF while cooling with an ice bath and the mixture was stirred for 15 min at this temperature. Then 2.2 mL (17 mmol) benzenesulphonic acid chloride were added and stirred overnight at RT. The reaction mixture was combined with water and EtOAc and extracted several times with EtOAc. The combined organic phases were dried on sodium sulphate and evaporated down.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-54723267a08c44ae9c7b22df19a3b48f |
| 출처 메모 | uspto-grants-2014_09 |