反应详情

0.89 g (22 mmol) sodium hydride (60%) were added to 2.0 g (17 mmol) indole in 30 mL THF while cooling with an ice bath and the mixture was stirred for 15 min at this temperature. Then 2.2 mL (17 mmol) benzenesulphonic acid chloride were added and stirred overnight at RT. The reaction mixture was combined with water and EtOAc and extracted several times with EtOAc. The combined organic phases were dried on sodium sulphate and evaporated down.

1. temperaturewhile cooling with an ice bath
2. stirringstirred overnight at RT
3. extractionextracted several times with EtOAc
4. customThe combined organic phases were dried on sodium sulphate
5. customevaporated down