Sodium Hydroxide → 2-ethyl-1H-indole

HRID 74589노트

반응식

HRID 74589 반응식
C1(S([N:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=[C:11]2[CH2:19][CH3:20])(=O)=O)C=CC=CC=1.[OH-].[Na+]>CCO>[CH2:19]([C:11]1[NH:10][C:18]2[C:13]([CH:12]=1)=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH3:20]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 100167951H-Indole, 2-ethyl-1-(phenylsulfonyl)-

생성물 1

HCID 38016182-ethyl-1H-indole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.2 g (4.2 mmol) 1-benzenesulphonyl-2-ethyl-1H-indole in 10 mL EtOH were combined with 5 mL of a (20 mmol) 4 N aqueous sodium hydroxide solution and refluxed for 8 h. Then the solvent was eliminated using the rotary evaporator and the residue was diluted with ice water. After acidifying with semi-concentrated aqueous hydrochloric acid the grease precipitated was extracted with ethyl acetate. The organic phase was dried on sodium sulphate, filtered off, evaporated down and dried.

후처리

  1. temperaturerefluxed for 8 h
  2. customthe rotary evaporator
  3. additionthe residue was diluted with ice water
  4. customprecipitated
  5. extractionwas extracted with ethyl acetate
  6. customThe organic phase was dried on sodium sulphate
  7. filtrationfiltered off
  8. customevaporated down
  9. customdried

출처 및 근거

ORD 기록
ord-003399a254d34568b19bee9374dea228
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

반응 노트

불러오는 중…