2-ethyl-1H-indole → 2-ethyl-2,3-dihydro-1H-indole

HRID 74590노트

반응식

HRID 74590 반응식
[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2].C([BH3-])#N.[Na+]>C(O)(=O)C>[CH2:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 38016182-ethyl-1H-indoleHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 107731212-ethyl-2,3-dihydro-1H-indole

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

0.66 g (4.2 mmol) 2-ethyl-1H-indole in 10 mL acetic acid were mixed with 1.3 g (20 mmol) sodium cyanoborohydride and stirred for one day at RT. The reaction mixture was evaporated down using the rotary evaporator, combined with 20 mL aqueous 4N hydrochloric acid and stirred for 1 h at RT. While cooling with ice 45 mL of an aqueous 4N sodium hydroxide solution were then added and the mixture was extracted with ethyl acetate. The organic phase was dried on sodium sulphate, filtered, evaporated down and the residue was dried in vacuo.

후처리

  1. customThe reaction mixture was evaporated down
  2. customthe rotary evaporator
  3. stirringstirred for 1 h at RT
  4. temperatureWhile cooling with ice 45 mL of an aqueous 4N sodium hydroxide solution
  5. additionwere then added
  6. extractionthe mixture was extracted with ethyl acetate
  7. customThe organic phase was dried on sodium sulphate
  8. filtrationfiltered
  9. customevaporated down
  10. customthe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-165e068de69048f2b2016b2a8ecdc74d
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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