Potassium cyanate → N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea

HRID 745922노트

반응식

HRID 745922 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:4][CH:3]=1.[O-:16][C:17]#[N:18].[K+]>Cl.O>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)=[CH:14][CH:15]=1)[C:17]([NH2:18])=[O:16]

참가 물질

5

반응물 2

HCID 11378442Potassium cyanateHCID 135692034-[2-(1H-Imidazol-1-yl)ethoxy]aniline

생성물 1

HCID 13569204N-[4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]urea수율 82.5%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

1-[2-(4-Aminophenoxy)ethyl]imidazole (0.6 g) was dissolved in 1N hydrochloric acid (3.0 ml) and a solution of potassium cyanate (0.3 g) in 1 ml of water was added. The mixture was allowed to stand at room temperature for 15 minutes and the resulting solid was filtered off, washed with water and crystallised from water to give 1-[2-(4-ureidophenoxy)ethyl]imidazole (0.6 g), m.p. 199°-201° C. Found: C, 58.20; H, 5.70; N, 23.06. C12H14N4O2 requires: C, 58.52; H, 5.73; N, 22.75%.

후처리

  1. filtrationthe resulting solid was filtered off
  2. washwashed with water
  3. customcrystallised from water

출처 및 근거

ORD 기록
ord-acc04cf877aa4dcd9b62f88b27580a76
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602016

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