Hydrazine hydrate (1:1) → HCID 13656051, 화합물

HRID 745931노트

반응식

HRID 745931 반응식
[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11](=O)[CH:10]([CH2:16][C:17]([OH:19])=O)[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:21][NH2:22]>C(O)C>[N:1]1([C:6]2[CH:7]=[C:8]3[C:12](=[CH:13][CH:14]=2)[C:11]2=[N:21][NH:22][C:17](=[O:19])[CH2:16][CH:10]2[CH2:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 13656050[5-(1H-Imidazol-1-yl)-1-oxo-2,3-dihydro-1H-inden-2-yl]acetic acid

생성물 1

HCID 13656051HCID 13656051, 화합물수율 48%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 1.48 g of 2,3-dihydro-5-(1H-imidazol-1-yl)-1-oxo-1H-indene-2-acetic acid and 0.38 g of 85% hydrazine hydrate in 15 ml of ethanol is heated to reflux for three hours. The reaction mixture is filtered, the residue is washed with ethanol and purified by crystallization from ethanol to give 0.7 g of the product, 2,4,4a,5-tetrahydro-7-(1H-imidazol-1-yl)-3H-indeno[1,2-c]pyridazin-3-one, mp 263°-264° dec.

후처리

  1. temperatureto reflux for three hours
  2. filtrationThe reaction mixture is filtered
  3. washthe residue is washed with ethanol
  4. custompurified by crystallization from ethanol

출처 및 근거

ORD 기록
ord-e0e5d4a25264406f8fcb0cc7bc50efba
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602019

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