Methanol → (5-Bromo-4-chloropyridin-2-yl)methanol

HRID 74596노트

반응식

HRID 74596 반응식
FC(F)(F)C(O[C:6](=[O:11])[C:7](F)(F)F)=O.[Br:14][C:15]1[C:16]([Cl:23])=[CH:17]C(C)=[N+:19]([O-])[CH:20]=1.CO>C(Cl)Cl>[Br:14][C:15]1[C:16]([Cl:23])=[CH:17][C:7]([CH2:6][OH:11])=[N:19][CH:20]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 9845Trifluoroacetic anhydrideHCID 136827785-Bromo-4-chloro-2-methylpyridine 1-oxide

생성물 1

HCID 19791171(5-Bromo-4-chloropyridin-2-yl)methanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3.0 mL trifluoroacetic anhydride were added dropwise at 10° C. to 2.6 g (12 mmol) 5-bromo-4-chloro-2-methylpyridine-1-oxide in 30 mL DCM. The reaction mixture was stirred for 5 days at RT. After the addition of MeOH the reaction mixture was evaporated down, the residue was combined with 15% potassium carbonate solution and extracted several times with EtOAC. The combined organic phases were dried on sodium sulphate and evaporated down.

후처리

  1. customwas evaporated down
  2. extractionextracted several times with EtOAC
  3. customThe combined organic phases were dried on sodium sulphate
  4. customevaporated down

출처 및 근거

ORD 기록
ord-3c280e930d3a4fb9aa6a1b2618d9a15a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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