Hydrogen Peroxide → 2-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid

HRID 745988노트

반응식

HRID 745988 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17][C:18]([CH3:23])([CH3:22])[C:19]([OH:21])=[O:20])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH:24]O>C(O)(=O)C.Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([S:17]([C:18]([CH3:23])([CH3:22])[C:19]([OH:21])=[O:20])=[O:24])=[CH:16][C:11]=3[O:10][N:9]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 140125362-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]thio]-2-methylpropionic acid

생성물 1

HCID 136560912-[[3-(4-Chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid수율 58%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매

실험 절차

5.56 g (16.0 mmol) of 2-[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]thio]-2-methylpropionic acid and 6 ml of 30% H2O2 were combined in 200 ml glacial acetic acid. The mixture was stirred at room temperature and monitored by TLC for the disappearance of starting material and the appearance of product. After about four hours the reaction was stopped by diluting with excess 3N HCl. The resulting precipitate was filtered and washed several times with cold toluene to yield white crystals, 3.38 g (58%) of 2-[[3-(4-chlorophenyl)-1,2-benzisoxazol-6-yl]sulfinyl]-2-methylpropionic acid, m.p. 184°-185° C.

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed several times with cold toluene

출처 및 근거

ORD 기록
ord-64a897c576b4455899f8b587f161f1d8
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602028

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