Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromobenzoic acid → (3-Bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromobenzoic acid | HCID 11456 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 5-Fluoroindoline | HCID 2774463 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (3-Bromo-phenyl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58386659 | — |
반응 단계
0.40 g (2.0 mmol) 3-bromobenzoic acid and 0.28 g (2.0 mmol) 5-fluoro-2,3-dihydro-1H-indole in 0.55 mL (4.0 mmol) TEA and 10 mL DCM were combined with 0.64 mg (2.0 mmol) TBTU and stirred overnight at RT. The reaction mixture was extracted with saturated sodium hydrogen carbonate solution and DCM. The combined organic phases were dried on sodium sulphate, filtered and evaporated down. The residue was suspended in MeOH, suction filtered and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-aeea0957623645d79d3c0b98b15ffdd9 |
| 출처 메모 | uspto-grants-2014_09 |