Diketene → Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester

HRID 746242

반응식

HRID 746242 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH:7]([N:20]1[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][OH:28])[CH2:22][CH2:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:4]([O:28][CH2:27][CH2:26][N:23]1[CH2:22][CH2:21][N:20]([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:25][CH2:24]1)(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

참가 물질

3

반응물 2

HCID 12661DiketeneHCID 47425734-(Diphenylmethyl)-1-piperazineethanol

생성물 1

HCID 11740518Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester

실험 절차

Diketene (5.1 g) was added to 4-benzhydryl-1-piperazineethanol (18.1 g) and the mixture was heated at 70°-80° C. with stirring for 1.5 hours and purified by silica gel chromatography [eluent: hexane-ethyl acetate (3:2)] to give 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate as an oil. Yield 17.1 g (73.6%).

후처리

  1. temperaturethe mixture was heated at 70°-80° C.
  2. custompurified by silica gel chromatography [eluent: hexane-ethyl acetate (3:2)]

출처 및 근거

ORD 기록
ord-a0bbfa319da6425384492eba69d87e94
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04603135

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