Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diketene → Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diketene | HCID 12661 | — |
| 반응물 | 4-(Diphenylmethyl)-1-piperazineethanol | HCID 4742573 | — |
| 생성물 | Butanoic acid, 3-oxo-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl ester | HCID 11740518 | — |
반응 단계
Diketene (5.1 g) was added to 4-benzhydryl-1-piperazineethanol (18.1 g) and the mixture was heated at 70°-80° C. with stirring for 1.5 hours and purified by silica gel chromatography [eluent: hexane-ethyl acetate (3:2)] to give 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate as an oil. Yield 17.1 g (73.6%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04603135 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-a0bbfa319da6425384492eba69d87e94 |
| 출처 메모 | uspto-grants-1986_07 |