Sodium borohydride → HCID 58687965, 화합물
반응식
[Br:1][C:2]1[C:9]([O:10][CH3:11])=[N:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]([Br:16])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C(O)C>[Br:1][C:2]1[C:9]([O:10][CH3:11])=[N:8][C:7]([C:12]([F:15])([F:14])[F:13])=[C:6]([Br:16])[C:3]=1[CH2:4][OH:5]참가 물질
4
실험 절차
To a solution of 3,5-dibromo-2-methoxy-6-(trifluoromethyl)isonicotinaldehyde (980 mg, 2.7 mmol) in ethanol (10 mL), was added sodium borohydride (102 mg, 2.7 mmol). The reaction mixture was stirred for 20 min, concentrated, and the residue was purified by flash column (silica gel, 50% EtOAc/hexane) to yield [3,5-dibromo-2-methoxy-6-(trifluoromethyl)pyridin4-yl]methanol (717 mg, 72.8%). 1H-NMR (400 MHz, CDCl3) δ 5.10 (s, 2H), 4.05 (s, 3H), 2.32 (br s, 1H).
후처리
- concentrationconcentrated
- customthe residue was purified by flash column (silica gel, 50% EtOAc/hexane)
출처 및 근거
- ORD 기록
- ord-f9b1d6b88a5d4e038f3082983fb404f9
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07393844B2
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