Dimethylformamide → 6-Morpholinonicotinoyl Chloride

HRID 746512

반응식

HRID 746512 반응식
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25]C(C(O)=O)=[CH:20][N:19]=2)[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25][C:6]([C:7]([Cl:9])=[O:8])=[CH:20][N:19]=2)[CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27764606-Morpholinonicotinic Acid

생성물 1

HCID 27764616-Morpholinonicotinoyl Chloride

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

N,N-Dimethylformamide (1 mL) was slowly added to a solution of oxalyl chloride (0.13 g, 1 mmol) in chloroform (5 mL). 6-Morpholinonicotinic acid (0.21 g, 1 mmol) was added and the reaction mixture was stirred for 15 minutes. The reaction mixture was concentrated under vacuum, diluted with toluene and then concentrated under vacuum to provide 6-morpholinonicotinoyl chloride. This material was kept under vacuum at ambient temperature overnight and then used in the next step.

후처리

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additiondiluted with toluene
  3. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-54d88a15fe754b5889ed92f48cc82849
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393859B2

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