Bromine → HCID 821949, 화합물
반응식
[S:1]1[C:5]([CH2:6][CH2:7][OH:8])=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[Br:13]Br.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:13][C:4]1[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=2[S:1][C:5]=1[CH2:6][CH2:7][OH:8]참가 물질
5
실험 절차
To a cooled solution (0° C.) of 2-benzo[b]thiophen-2-yl-ethanol (5 g, 28.1 mmol) in CHCl3 (30 mL), bromine (1.73 mL, 33.7 mmol) was added dropwise. The reaction was stirred overnight while gradually being warmed to room temperature. Saturated NaHCO3 was added and the organic layer was separated. The aqueous layer was subsequently extracted with dichloromethane and the combined organic layers were dried (Na2SO4) and concentrated in vacuo to afford 2-(3-bromo-benzo[b]thiophen-2-yl)-ethanol in quantitative yield.
후처리
- customthe organic layer was separated
- extractionThe aqueous layer was subsequently extracted with dichloromethane
- dry with materialthe combined organic layers were dried (Na2SO4)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-7b336e57dc5e410db07b2ddcb4028c5a
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07393865B2
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