Bromoacetonitrile → HCID 86613167, 화합물

HRID 746765노트

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HRID 746765 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([Br:10])=[C:6]([CH:9]=1)[C:7]#[N:8].[CH:11]([N:14](CC)C(C)C)(C)[CH3:12].BrCC#N>C1COCC1>[Br:10][C:5]1[CH:4]=[CH:3][C:2]([NH:1][CH2:12][C:11]#[N:14])=[CH:9][C:6]=1[C:7]#[N:8]

참가 물질

5

반응물 3

HCID 11534BromoacetonitrileHCID 81531DiisopropylethylamineHCID 8172085-amino-2-bromobenzonitrile

생성물 1

HCID 86613167HCID 86613167, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

Mix 5-amino-2-bromobenzonitrile (0.76 mmol) in anhydrous THF (3 ml), N,N-diisopropylethylamine (0.92 mmol), and bromoacetonitrile (1.0 mmol) at room temperature under inert atmosphere. Heat the mixture to 100° C. for 16 h in a sealed tube. Cool in ice bath, filter the precipitate and evaporate the filtrate to dryness to afford a crude residue. Purify by flash chromatography (Silica gel-CHCl3/Ethanol/NH4OH 9:1:0.1) to yield the title compound.

후처리

  1. temperatureCool in ice bath
  2. filtrationfilter the precipitate
  3. customevaporate the filtrate to dryness
  4. customto afford a crude residue
  5. customPurify by flash chromatography (Silica gel-CHCl3/Ethanol/NH4OH 9:1:0.1)

출처 및 근거

ORD 기록
ord-9db4380ff0ae4557a0aa881d69f64b9a
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393868B2

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