Sodium Chloride → 4-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester

HRID 746767

반응식

HRID 746767 반응식
[O-:1][S:2]([O-:5])(=O)=O.[Na+].[Na+].[CH3:8][O:9][C:10](=[O:19])[C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[C:13]([NH2:18])[CH:12]=1.[CH3:20]CN(CC)CC.[Na+].[Cl-]>ClCCl>[CH3:8][O:9][C:10](=[O:19])[C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[C:13]([NH:18][S:2]([CH3:20])(=[O:5])=[O:1])[CH:12]=1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 24436Sodium SulfateHCID 3928639Methyl 3-amino-4-bromobenzoate

생성물 1

HCID 692544444-Bromo-3-(methanesulfonylamino)-benzoic acid methyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Add Na2SO4 (0.12 mmol) to a suspension of 4-Bromo-3-amino-benzoic acid methyl ester (0.1 mmol) and Et3N (0.1 mmol) in dichloromethane at 0° C. Stir 4 h at RT. Add a saturated solution of NaCl (15 mL), and extract with dichloromethane (2×50 mL). Dry over NaSO4, filter and evaporate to dryness. Purify the residue utilizing flash chromatography (Silica gel-hexane/EtOAc) to provide the title compound.

후처리

  1. extractionextract with dichloromethane (2×50 mL)
  2. dry with materialDry over NaSO4
  3. filtrationfilter
  4. customevaporate to dryness
  5. customPurify the residue utilizing flash chromatography (Silica gel-hexane/EtOAc)

출처 및 근거

ORD 기록
ord-b097c323dd0c44d9ba4d4ac2d7d18996
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393868B2

연결된 노트

불러오는 중…