Hydrochloric Acid → 1-Oxa-8-azaspiro(4.5)decane hydrochloride

HRID 747007노트

반응식

HRID 747007 반응식
[ClH:1].O1[C:6]2([CH2:11][CH2:10][CH:9]([C:12]([O:14]C(C)(C)C)=O)CC2)[CH2:5][NH:4][CH2:3]1.[CH3:19]O>>[ClH:1].[O:14]1[C:11]2([CH2:19][CH2:3][NH:4][CH2:5][CH2:6]2)[CH2:10][CH2:9][CH2:12]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 692216311,1-Dimethylethyl 1-oxa-3-azaspiro[4.5]decane-8-carboxylate

생성물 1

HCID 219349811-Oxa-8-azaspiro(4.5)decane hydrochloride수율 98%

실험 절차

Methanolic hydrogen chloride (3M, 20 ml) was added over 10 minutes to a stirred, cooled (0° C.) solution of 1,1-dimethylethyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iv) above, 3.18 g, 13.2 mmol) in methanol (10 ml) and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to give the title compound (2.29 g, 98%).

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2a85b5a462b848fc85e65a26dde730bf
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07393858B2

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