Propylamine → 4,6-Di(2-furyl)-5-[2-(propylamino)-4-pyridyl]-2-pyrimidinamine

HRID 747165노트

반응식

HRID 747165 반응식
F[C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:20]3[O:21][CH:22]=[CH:23][CH:24]=3)=[N:10][C:11]([NH2:19])=[N:12][C:13]=2[C:14]2[O:15][CH:16]=[CH:17][CH:18]=2)[CH:5]=[CH:4][N:3]=1.[CH2:25]([NH2:28])[CH2:26][CH3:27]>>[O:21]1[CH:22]=[CH:23][CH:24]=[C:20]1[C:9]1[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:28][CH2:25][CH2:26][CH3:27])[CH:7]=2)=[C:13]([C:14]2[O:15][CH:16]=[CH:17][CH:18]=2)[N:12]=[C:11]([NH2:19])[N:10]=1

참가 물질

3

반응물 2

HCID 7852PropylamineHCID 23020419HCID 23020419, 화합물

생성물 1

HCID 597490934,6-Di(2-furyl)-5-[2-(propylamino)-4-pyridyl]-2-pyrimidinamine수율 64%

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온도
120 °C

실험 절차

In a reaction vessel, 5-(2-fluoro-4-pyridyl)-4,6-di(2-furyl)-2-pyrimidinamine (200 mg, 0.621 mmol) and n-propylamine (5 ml) were mixed together and the mixture was stirred at 120° C. After 18 hours, the reaction mixture was extracted with ethyl acetate, and the extract was washed with water and brine, dried over anhydrous sodium sulfate and then the filtrate was concentrated. The resulting solid was suspended in ethanol, collected by filtration and washed with ethanol, to give the title compound (64%,72 mg) as a pale yellow solid.

후처리

  1. extractionthe reaction mixture was extracted with ethyl acetate
  2. washthe extract was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationthe filtrate was concentrated
  5. filtrationcollected by filtration
  6. washwashed with ethanol

출처 및 근거

ORD 기록
ord-cb2fec0bde784a8fb04f504fae7bee61
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396836B2

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