(3-Methylpyridin-2-yl)methanol → 3-Methylpyridine-2-carboxaldehyde

HRID 747342

반응식

HRID 747342 반응식
[OH:1][CH2:2][C:3]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:8]1[C:3]([CH:2]=[O:1])=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 1514369(3-Methylpyridin-2-yl)methanol

생성물 1

HCID 15018743-Methylpyridine-2-carboxaldehyde수율 64%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 2-(hydroxymethyl)-3-methylpyridine (1.08 g, 8.77 mmol) in dry CH2Cl2 (45 mL) at room temperature was added MnO2 (8.09 g, 79.1 mmol). The mixture was stirred for 21 hrs then filtered through celite. The filtrate was concentrated to give 0.68 g (64%) of 3-methylpyridine-2-carboxaldehyde. 1H NMR (CDCl3) □ 2.66 (s, 3H), 7.39 (dd, 1H, J=8.3, 4.3 Hz), 7.63 (d, 1H, J=7.9 Hz), 8.66 (d, 1H, J=3.3 Hz), 10.19 (s, 1H). This was used without further purification.

후처리

  1. filtrationthen filtered through celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-79276cd25702424f90854d58f89435ed
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396840B2

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