Hydrochloric Acid → (2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanol

HRID 747604노트

반응식

HRID 747604 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])=[O:12])([O-])=O.[Sn].Cl>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[Cl:19])[OH:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 68569266(2-Nitro-5-fluorophenyl)(2-chlorophenyl)methanone

생성물 1

HCID 68567746(2-Amino-5-fluorophenyl)-(2-chlorophenyl)methanol수율 100.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 0.5 g of (2-nitro-5-fluorophenyl)(2-chlorophenyl)methanone dissolved in 10 ml of ethanol are added 0.44 g of tin and 1.5 ml of 12M hydrochloric acid, and the mixture is left for 3 hours at room temperature. The reaction medium is concentrated and the residue is taken up in ethyl acetate and washed with 2M sodium hydroxide solution and then with saturated ammonium chloride solution. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 0.453 g of the expected product.

후처리

  1. concentrationThe reaction medium is concentrated
  2. washwashed with 2M sodium hydroxide solution
  3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a38e9f99595b444aaffe62b79dc614b5
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07396958B2

반응 노트

불러오는 중…