Sodium borohydride → (2-Amino-5-chlorophenyl)(2,5-dichlorophenyl)methanol
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[Cl:18])=[O:10].[BH4-].[Na+]>C(O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]([C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[Cl:18])[OH:10]참가 물질
4
실험 절차
To 6.38 g of (2-amino-5-chlorophenyl)(2,5-dichlorophenyl)methanone dissolved in 50 ml of ethanol are added 2.4 g of sodium borohydride, and the mixture is left for 18 hours at room temperature. The resulting mixture is concentrated and the residue is taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 2.016 g of the expected product.
후처리
- concentrationThe resulting mixture is concentrated
- washwashed with water
- dry with materialThe organic phase is dried over anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-d79a53f8faef4b29b48ac87440ffcc58
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07396958B2
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